Example of “Systems Thinking”– Reconsidering mental models, in this case the role of inflammation in diseases such as cancer is developed in this paper, published in 2004 in the “Journal of Inflammation”.
Cancer, inflammation and the AT1 and AT2 receptors
Authors: Gary Robert Smith and Sotiris Missailidis
The critical role of inappropriate inflammation is becoming accepted in many diseases that affect man, including cardiovascular diseases, inflammatory and autoimmune disorders, neurodegenerative conditions, infection and cancer. Based on current literature and clinical studies on angiotensin receptor inhibitors, the paper concludes that blockade of the AT1 receptor in synergy with cancer vaccines and anti-inflammatory agents should offer a therapy to regress most, if not all, solid tumours.